Premium
Direct chromatographic separation of 2‐arylpropionic acid enantiomers using tris(3,5‐dimethylphenylcarbamate)s of cellulose and amylose as chiral stationary phases
Author(s) -
Okamoto Yoshio,
Aburatani Ryo,
Kaida Yuriko,
Hatada Koichi,
Inotsume Nobuo,
Nakano Masahiro
Publication year - 1989
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530010310
Subject(s) - chemistry , flurbiprofen , enantiomer , chromatography , amylose , cellulose , tris , ibuprofen , ketoprofen , resolution (logic) , high performance liquid chromatography , chiral stationary phase , organic chemistry , starch , medicine , biochemistry , artificial intelligence , computer science , pharmacology
Direct optical resolution of antiinflammatory drugs such as ibuprofen, ketoprofen, flurbiprofen, and tiaprofenic acid were attempted by high‐performance liquid chromatography using tris(3,5‐dimethylphenylcarbamate)s of cellulose and amylose as chiral stationary phases. Although ibuprofen was not sufficiently resolved, the other three 2‐arylpropionic acids were completely resolved by amylose tris(3,5‐dimethylphenylcarbamate). Ibuprofen was resolved as anilide derivative.