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Optical resolution of β‐lactams by chiral HPLC on tris(phenylcarbamate)s of cellulose and amylose
Author(s) -
Okamoto Yoshio,
Senoh Toshiaki,
Nakane Harumi,
Hatada Koichi
Publication year - 1989
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530010307
Subject(s) - chemistry , diastereomer , amylose , cellulose , resolution (logic) , high performance liquid chromatography , chromatography , tris , absolute configuration , organic chemistry , biochemistry , artificial intelligence , starch , computer science
Abstract Separation and optical resolution of 6 diastereomers and 25 racemates of β‐lactams were examined by HPLC on chiral stationary phases composed of six cellulose and one amylose tris(phenylcarbamate) derivatives. Most β‐lactams were optically resolved at least by one of the derivatives. The absolute configuration of β‐lactams was estimated by CD spectroscopy.