Premium
Methiodide of the GABA antagonist (+)‐bicuculline is levorotatory
Author(s) -
Simonyi Miklós,
Blaskó Gábor,
Kardos Julianna,
Kajtár Márton
Publication year - 1989
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530010214
Subject(s) - methiodide , chemistry , bicuculline , moiety , antagonist , enantiomer , stereochemistry , pharmacology , biochemistry , receptor , medicine
The appearance of positive charge on the nitrogen moiety of phthalideisoquinoline alkaloids brings about a strong change in the intensities of CD Cotton effects. Hence the optical rotations of enantiomeric salts and their parent base of identical configuration are often of opposite sign. Thus, the name (+)‐bicuculline‐methiodide for the methiodide salt of (+)‐bicuculline is false.