Investigation on the enantiomeric impurity of epinephrine hydrochloride injections | Zendy

ZhongYuan Yang | Zendy; RuZheng Xu | Zendy

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Investigation on the enantiomeric impurity of epinephrine hydrochloride injections

Author(s) -

ZhongYuan Yang,

RuZheng Xu

Publication year - 1989

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.530010117

Subject(s) - chemistry , diastereomer , enantiomer , epinephrine , reagent , hydrochloride , chromatography , impurity , resolution (logic) , organic chemistry , anesthesia , medicine , artificial intelligence , computer science

Epinephrine enantiomers were derived into diastereoisomers with the chiral reagent 2,3,4,6‐tetra‐ O ‐acetyl‐β‐D‐glucopyranosylisothiocyanate. The resolutions was carried out on a C 18 column. The R S between (−)‐R‐ and (+)‐S‐isomers was 2.3. The retention time could be changed by adding a proper amount of acetonirile into the mobile phase. The results showed that (+)‐S‐isomer in the epinephrine hydrochloride injections increased during the period of storage.

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