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Investigation on the enantiomeric impurity of epinephrine hydrochloride injections
Author(s) -
ZhongYuan Yang,
RuZheng Xu
Publication year - 1989
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530010117
Subject(s) - chemistry , diastereomer , enantiomer , epinephrine , reagent , hydrochloride , chromatography , impurity , resolution (logic) , organic chemistry , anesthesia , medicine , artificial intelligence , computer science
Epinephrine enantiomers were derived into diastereoisomers with the chiral reagent 2,3,4,6‐tetra‐ O ‐acetyl‐β‐D‐glucopyranosylisothiocyanate. The resolutions was carried out on a C 18 column. The R S between (−)‐R‐ and (+)‐S‐isomers was 2.3. The retention time could be changed by adding a proper amount of acetonirile into the mobile phase. The results showed that (+)‐S‐isomer in the epinephrine hydrochloride injections increased during the period of storage.