Premium
Stereocontrolled synthesis of peptide bond isosteres
Author(s) -
Whitesell James K.,
Lawrence Robert M.
Publication year - 1989
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530010116
Subject(s) - chemistry , peptide , peptide bond , combinatorial chemistry , stereochemistry , biochemistry
Absolute stereochemical control is employed in the synthesis of isosteres for dipeptide subunits 1; see Fig. (1) in which the amide linkage has been replaced by a trans carbon‐caron double bond. The synthesis affords access to the four stereoisomers of 1 in which R and R' = CH 3 , including the isostere of D‐alanine‐d‐alanine (D‐ala‐D‐Ala), 2.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom