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Preparation of chiral statonary phase from an α‐amino phosphonate
Author(s) -
Pirkle William H.,
Burke John A.
Publication year - 1989
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.530010111
Subject(s) - chemistry , enantiomer , phosphonate , chiral stationary phase , selectivity , phase (matter) , stereochemistry , chirality (physics) , combinatorial chemistry , organic chemistry , catalysis , chiral symmetry , nambu–jona lasinio model , physics , quantum mechanics , quark
A chiral statonary phase (CSP) derived from an N ‐(3,5‐dinitrobenzoyl)‐α‐aminobenzylphosphonate has been prepared and evaluated for its utility in the direct separation of enantiomers. This CSP, 2, is structurally related to earlier N ‐(3,5‐dinitrobenzoyl)‐α‐acids acid‐derived phases (e.g., CSP 1), but the mode of attachment to the support is different. In scope; CSP 2 is qualitaively similar to CSP 1. However, it differs quantitatively from CSP 1, showing either greater or lesser selectivity for different pairs of enantiomers.