Premium
Enantioselective conjugate addition of pyrazolones to nitroalkenes catalyzed by chiral squaramide organocatalyst
Author(s) -
Aydin Alime Ebru,
Culha Selda
Publication year - 2021
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23295
Subject(s) - squaramide , chemistry , enantioselective synthesis , conjugate , pyrazolones , catalysis , combinatorial chemistry , organic chemistry , organocatalysis , mathematical analysis , mathematics
The chiral squaramide catalysts (8–15) were synthesized, and their catalytic efficiency in the enantioselective conjugate addition of pyrazolones to nitroalkenes was described. This protocol provides excellent chemical yields (up to 93%) of chiral 5‐methyl‐4‐(2‐nitro‐1‐arylethyl)pyrazol‐3‐ol derivatives with high enantioselectivities (up to 97% ee).