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Multimilligram‐scale production implementation of atropisomers of 2,2′‐bis(2,2′‐bithiophene‐5‐yl)‐3,3′‐bithianaphthene
Author(s) -
Rosetti Alessia,
Bonetti Giorgia,
Villani Claudio,
Benincori Tiziana,
Cirilli Roberto
Publication year - 2021
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23294
Subject(s) - chemistry , enantiomer , enantioselective synthesis , atropisomer , high performance liquid chromatography , chiral column chromatography , monomer , chromatography , organic chemistry , catalysis , polymer
2,2′‐Bis[2‐(5,2′‐bithienyl)]‐3,3′‐bithianaphthene ( 1 ) is the progenitor of a class of C 2 symmetric thiophene‐based electroactive monomers that, when electrooxidized in the enantiomerically pure form, produce inherently chiral films endowed with outstanding electrochemical enantiorecognition properties. The enantioselective high‐performance liquid chromatography (HPLC) is the only approach used so far to resolve the racemic form of 1 into enantiomers. In this work, an improved HPLC method for multimilligram enantiomer production is presented. Key factors controlling the enantioseparation, such as mobile phase composition and column temperature, were identified using a 100 × 4.6 mm i.d. Chiralpak IB‐3 column and subsequently scaled up to a 250 × 10.0 mm i.d. Chiralpak IB column. In the optimized semipreparative conditions, about 34 mg of pure (P ) and ( M ) enantiomers per hour could be produced.