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Observation of hyperpositive non‐linear effect in catalytic asymmetric organozinc additions to aldehydes
Author(s) -
Geiger Yannick,
Achard Thierry,
MaisseFrançois Aline,
BelleminLaponnaz Stéphane
Publication year - 2020
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23271
Subject(s) - enantiopure drug , chemistry , enantioselective synthesis , catalysis , homochirality , mechanism (biology) , computational chemistry , organic chemistry , enantiomer , physics , quantum mechanics
Asymmetric amplification is a phenomenon that is believed to play a key role in the emergence of homochirality in life. In asymmetric catalysis, theoretical and experimental models have been investigated to provide an understanding of how chiral amplification is possible, in particular based on non‐linear effects. Interestingly, it has been proposed a quarter century ago that chiral catalysts, when not enantiopure might even be more enantioselective than their enantiopure counterparts. We show here that such hyperpositive non‐linear effect in asymmetric catalysis is indeed possible. An in‐depth study into the underlying mechanism was carried out, and the scheme we derive differs from the previous proposed models.