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Enantioanalysis of tryptophan in whole blood samples using stochastic sensors—A screening test for gastric cancer
Author(s) -
IlieMihai RuxandraMaria,
Stefanvan Staden RalucaIoana,
Magerusan Lidia,
Coros Maria,
Pruneanu Stela
Publication year - 2020
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23155
Subject(s) - tryptophan , chemistry , cancer , protoporphyrin ix , whole blood , biochemistry , chromatography , computational biology , amino acid , medicine , organic chemistry , biology , photodynamic therapy
Tryptophan is a key amino acid related to metabolomics in gastric cancer. To date, methods were developed only for the assay of l ‐tryptophan, the role of d ‐tryptophan being not yet established. Therefore, four stochastic sensors based on different graphene materials modified with β‐cyclodextrins, 2,2‐diphenyl‐1‐picrylhydrazyl, and protoporphyrin IX were designed and used for enantioanalysis of tryptophan in whole blood samples. High sensitivities, and reliabilities were recorded when the stochastic sensors were used for the enantioanalysis of tryptophan in whole blood samples. The paper opened a new chapter in early detection of gastric cancer, based on establishing the role of d ‐tryptophan in metabolomics, and in early diagnosis of gastric cancer.