Co(II)‐salen catalyzed stereoselective cyclopropanation of fluorinated styrenes | Zendy

Tai Serene | Zendy; Maskrey Taber S. | Zendy; Nyalapatla Prasanth R. | Zendy; Wipf Peter | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Co(II)‐salen catalyzed stereoselective cyclopropanation of fluorinated styrenes

Author(s) -

Tai Serene,

Maskrey Taber S.,

Nyalapatla Prasanth R.,

Wipf Peter

Publication year - 2019

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.23144

Subject(s) - cyclopropanation , chemistry , steric effects , ethyl diazoacetate , stereoselectivity , enantiomer , catalysis , enantioselective synthesis , ligand (biochemistry) , chirality (physics) , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry , nambu–jona lasinio model , chiral symmetry breaking , physics , quantum mechanics , quark

Three cis ‐selective Co(II)‐salen complexes have been developed for the asymmetric cyclopropanation of para ‐fluorinated styrenes with ethyl diazoacetate. Increasing the steric reach of the C 2 ‐symmetric ligand side chains improved the enantiomeric ratio of the reaction from 28:1 to 66:1. The methodology was exemplified by the gram‐scale synthesis of a lead compound for the treatment of castration‐resistant prostate cancer (CRPC), as well as a structurally related analog.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research