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Practical method for increasing optical purity of cis ‐verbenol
Author(s) -
Kovalenko Vitaly,
Krauchanka Aliaksei,
Prokhorevich Konstantin
Publication year - 2019
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23119
Subject(s) - chemistry , stereochemistry , nanotechnology , materials science
R / S mixture of monoterpene alcohol cis ‐verbenol can be separated in preparative scale by its conversion into phthalic mono ‐ester and subsequent crystallization of its diastereomeric salts with ( R )‐α‐methylbenzylamine and ( S )‐α‐methylbenzylamine. Finally, basic methanolysis of the resolved phthalic mono ‐esters results ( S )‐ cis ‐verbenol and ( R )‐ cis ‐verbenol in high enantiomeric and diastereomeric purity.