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Enantioselective hydrogenation of α‐ketoesters catalyzed by cinchona alkaloid stabilized Rh nanoparticles in ionic liquid
Author(s) -
Jiang Heyan,
Xu Jie,
Sun Bin
Publication year - 2019
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23107
Subject(s) - cinchona , enantioselective synthesis , chemistry , ionic liquid , rhodium , catalysis , cinchona alkaloids , enantiomer , cinchonidine , organic chemistry , asymmetric hydrogenation , nanoparticle , enantiomeric excess , ionic bonding , combinatorial chemistry , chemical engineering , engineering , ion
Abstract The heterogeneous enantioselective hydrogenation of α‐ketoesters catalyzed by rhodium nanoparticles (Rh NPs) in ionic liquid was studied with the stabilization and modification of cinchona alkaloids. TEM characterization showed that well‐dispersed Rh NPs of about 1.96 nm were obtained in ionic liquid. The results showed that cinchona alkaloids not only had good enantiodifferentiating ability but also accelerated the catalytic reaction. Under the optimum reaction conditions, the enantiomeric excess in ethyl benzoylformate hydrogenation could reach as high as 60.9%.