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Synthesis of novel chiral metal complexes derived from chiral thiosemicarbazide ligands as potential antioxidant agents
Author(s) -
Başaran Eyüp,
Sıcak Yusuf,
Sogukomerogullari Hatice Gamze,
KaraküçükIyidoğan Ayşegül,
OruçEmre Emine Elçin,
Sönmez Mehmet,
Öztürk Mehmet
Publication year - 2019
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23069
Subject(s) - chemistry , antioxidant , metal , ligand (biochemistry) , proton nmr , chelation , nuclear chemistry , stereochemistry , medicinal chemistry , photochemistry , organic chemistry , biochemistry , receptor
Two new chiral thiosemicarbazide ligands and their Cu (II), Ni (II), Pd (II), and Zn (II) complexes were synthesized and characterized by nuclear magnetic resonance (NMR) (only for ligand), Fourier transform infrared (FT‐IR), ultraviolet visible (UV‐Vis), mass, and elemental analysis. The antioxidant activity of ligands and their metal complexes was examined. It was found that the antioxidant activity of metal complexes was better than their ligands. In addition, the antioxidant activity, as reflected by free radical scavenging, was evaluated. Besides, Pd (II) complexes exhibited better antioxidant activity than Ni (II), Cu (II), and Zn (II) complexes. Therefore, complexes (3a‐Pd and 3b‐Pd) can be used as an antioxidant agent or antioxidant test standard.