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Atropisomerism in Rilpivirine hydrochloride: Spectroscopic characterization of Rilpivirine and related impurities
Author(s) -
Natarajan Senthilkumar,
Salmara Ganeshbhat Hiriyanna,
Shrivastava Sujeet,
Sankareswaran Srimurugan,
Kumar Pramod
Publication year - 2018
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22980
Subject(s) - rilpivirine , chemistry , atropisomer , impurity , analytical chemistry (journal) , chromatography , stereochemistry , organic chemistry , viral load , antiretroviral therapy , human immunodeficiency virus (hiv) , medicine , family medicine
Nuclear magnetic resonance (NMR) technique has been used to find the property of atropisomerism in Rilpivirine hydrochloride by variable temperature analysis and various 2D techniques. Both the Rilpivirine hydrochloride ( E ‐isomer) and Impurity‐A ( Z ‐isomer) isomers have been differentiated and confirmed by NMR and ultraviolet techniques. Preparative high‐performance liquid chromatography isolation for Impurity‐A is followed by spectroscopic (NMR, mass spectra, and infrared) investigation that provides a perfect solution for determination of the structure of Rilpivirine and related impurities.