Premium
The development of biphasic chiral recognition in chiral separation
Author(s) -
Huang XinYi,
Quan KaiJun,
Pei Dong,
Liu JianFei,
Di DuoLong
Publication year - 2018
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22975
Subject(s) - chemistry , enantiomer , chiral stationary phase , resolution (logic) , molecular recognition , chirality (physics) , chiral derivatizing agent , combinatorial chemistry , chromatography , chiral resolution , chiral column chromatography , nanotechnology , organic chemistry , artificial intelligence , computer science , molecule , chiral symmetry , materials science , physics , nambu–jona lasinio model , quark , quantum mechanics
In chiral separation, enantioseparation factor is an important parameter which influences the resolution of enantiomers. In this current overview, a biphasic chiral recognition method is introduced to the readers. This method can significantly improve the enantioseparation factor in two‐phase solvent through adding lipophilic and hydrophilic chiral selectors which have opposite chiral recognition ability to organic and aqueous phases, respectively. This overview presents the development and applications of biphasic chiral recognition in liquid‐liquid extraction and counter current chromatography. It mainly focuses on the topics of mechanism, advantages and limitations, applications, and key factors of biphasic chiral recognition. In addition, the future outlook on development of biphasic chiral recognition also has been discussed in this overview.