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Isothermal titration calorimetry for chiral chemistry
Author(s) -
Werber Liora,
Mastai Yitzhak
Publication year - 2018
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22842
Subject(s) - isothermal titration calorimetry , chemistry , chirality (physics) , enthalpy , gibbs free energy , entropy (arrow of time) , isothermal process , nanotechnology , computational chemistry , thermodynamics , chiral symmetry breaking , physics , materials science , quantum mechanics , nambu–jona lasinio model , quark
One of the most powerful techniques that are currently available to measure thermodynamic parameters such as enthalpy (Δ H ), Gibbs free energy (Δ G ), entropy changes (Δ S ), and binding affinity in chemical reactions is isothermal titration calorimetry (ITC). Recent advances in instrumentation have facilitated the development of ITC as a very essential analytical tool in biology and chemistry. In this article, we will focus on a review of the literature on the application of ITC for the study of chiral systems and chiral interactions. We present studies in which the ITC technique is used to study chiral interactions, for instance in chiral solutions, chiral organometallic complexes, guest‐host chiral binding interactions, and biological macromolecules. Finally, we put strong emphasis on the most recent application of ITC for the study of chirality in nanosystems and at the nanoscale.