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Analysis of stereoisomers of chiral drug by mass spectrometry
Author(s) -
Chen Xiaolei,
Kang Yu,
Zeng Su
Publication year - 2018
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22833
Subject(s) - chemistry , enantiomer , mechanism (biology) , mass spectrometry , chirality (physics) , combinatorial chemistry , chromatography , stereochemistry , chiral symmetry breaking , epistemology , philosophy , nambu–jona lasinio model , physics , quantum mechanics , quark
Chiral molecules are of great importance in the life science since individual enantiomers may differ in biological activity, mechanism, and toxicity, making it necessary to explore efficient chiral analysis methods. Chromatography approaches are often used to differentiate enantiomers while mass spectrometry (MS) was thought to be blind in chiral analysis. With the development of MS technique, it began to play a more and more crucial part in chiral observation. In this review, we will give a detailed introduction of the analysis methods related to MS for chiral drugs, including its mechanism, applications, and future development.