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An efficient and enantioselective Michael addition of aromatic oximes to α , β ‐unsaturated aldehydes promoted by a chiral diamine catalyst derived from α , α ‐diphenyl prolinol
Author(s) -
Chen Feng,
Ren HongXia,
Yang Yu,
Ji ShanPing,
Zhang ZhengBing,
Tian Fang,
Peng Lin,
Wang LiXin
Publication year - 2017
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22699
Subject(s) - chemistry , enantioselective synthesis , diamine , michael reaction , catalysis , organic chemistry , addition reaction , medicinal chemistry
Chiral diamine catalysts 11a–e derived from α , α ‐diphenyl prolinol were prepared and successfully applied to the Michael addition of aromatic oximes to α , β ‐unsaturated aldehydes in mediocre to good yields (up to 78%) and good to high enantioselectivities (up to 93% ee ).