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Solid‐phase extraction with metal–organic frameworks for the analysis of chiral compounds
Author(s) -
Tang Bo,
Zhang JunHui,
Zi Min,
Chen XueXian,
Yuan LiMing
Publication year - 2016
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22657
Subject(s) - chemistry , solid phase extraction , metal organic framework , extraction (chemistry) , enantiomer , adsorption , phase (matter) , chromatography , porosity , metal , combinatorial chemistry , analytical chemistry (journal) , organic chemistry
Metal–organic frameworks (MOFs) are excellent porous materials with nanoscale cavities and high surface areas, which make them promising as novel adsorbents in solid‐phase extraction (SPE). In this article we report a new application of the chiral MOF [Zn 2 (D‐Cam) 2 (4,4′‐bpy)] n in SPE used for the measurement of the enantiomeric excess ( ee ) of (±)‐1,1′‐bi‐2‐naphthol. Several important experimental parameters that may influence the extraction efficiency were investigated and optimized. Under the optimum conditions, a good linearity (R 2 > 0.999) was found between the ee value and the reciprocal of the peak areas. When compared with the actual ee measured using chiral HPLC, the SPE‐based assay also showed good accuracy and precision. The results showed that SPE based on chiral MOFs as adsorbents is a simple and effective method for the determination of the ee values of chiral compounds.