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Facile Diastereoseparation of Glycosyl Sulfoxides by Chiral Stationary Phase
Author(s) -
Taniguchi Tohru,
Asahata Mai,
Nasu Akihito,
Shichibu Yukatsu,
Konishi Katsuaki,
Monde Kenji
Publication year - 2016
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22610
Subject(s) - chemistry , glycosyl , phase (matter) , chiral stationary phase , combinatorial chemistry , organic chemistry , computational chemistry
Separation of the diastereomers of glycosyl sulfoxides differing in the sulfur chirality has been difficult. This article presents a fast and scalable method for their diastereoseparation using a chiral stationary phase. The usefulness of this method was demonstrated in a 500‐mg scale separation within 20 min, and in the separation of trisaccharyl sulfoxide diastereomers. Chirality 28:534–539, 2016 . © 2016 Wiley Periodicals, Inc.