Three Sesquiterpenoid Dimers from  Chloranthus japonicus : Absolute Configuration of Chlorahololide A and Related Compounds | Zendy

Shi XinWei | Zendy; Lu QiangQiang | Zendy; Pescitelli Gennaro | Zendy; Ivšić Trpimir | Zendy; Zhou JunHui | Zendy; Gao JinMing | Zendy

Premium

Three Sesquiterpenoid Dimers from Chloranthus japonicus : Absolute Configuration of Chlorahololide A and Related Compounds

Author(s) -

Shi XinWei,

Lu QiangQiang,

Pescitelli Gennaro,

Ivšić Trpimir,

Zhou JunHui,

Gao JinMing

Publication year - 2016

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.22561

Subject(s) - chemistry , absolute configuration , chirality (physics) , artemia salina , brine shrimp , stereochemistry , dimer , two dimensional nuclear magnetic resonance spectroscopy , organic chemistry , chiral symmetry , medicine , physics , toxicity , quantum mechanics , nambu–jona lasinio model , quark , traditional medicine

A novel sesquiterpenoid dimer, named multistalide C ( 1 ), together with two known congeners, shizukaols C ( 2 ) and D ( 3 ), was isolated from the whole plant of Chloranthus japonicus Sieb. The structures of compounds 1 , 2 , 3 were elucidated by extensive HR‐ESI‐MS, 1D, and 2D NMR spectroscopic analysis. Compounds 1 , 2 , 3 exhibited significant toxic effects on brine shrimp larvae ( Artemia salina ). The absolute configuration of 1 was established by CD/TDDFT calculations. The related compound chlorahololide A was also reinvestigated. The previous assignment of the absolute configuration of chlorahololide A and several related sesquiterpenoid dimers, based on an incorrect application of the exciton chirality method, is criticized. Chirality 28:158–163, 2015 . © 2015 Wiley Periodicals, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research