Effect of Different Z‐Inducers on the Stabilization of Z Portion in BZ‐DNA Sequence: Correlation Between Experimental and Simulation Data | Zendy

Pietropaolo Adriana | Zendy; D'urso Alessandro | Zendy; Purrello Roberto | Zendy; Berova Nina | Zendy

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Effect of Different Z‐Inducers on the Stabilization of Z Portion in BZ‐DNA Sequence: Correlation Between Experimental and Simulation Data

Author(s) -

Pietropaolo Adriana,

D'urso Alessandro,

Purrello Roberto,

Berova Nina

Publication year - 2015

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.22502

Subject(s) - chemistry , sequence (biology) , dna , inducer , correlation , stereochemistry , biophysics , biochemistry , gene , geometry , mathematics , biology

In this study we show the outstanding agreement between simulation and experimental data concerning the efficient stabilization effect by NaCl of Z conformation. We demonstrate by circular dichroism (CD) experiments that Na + not only is able to induce a B to Z form transition in a short (GC) 3 alternated portion of a sequence having 17 basis, but also is the best stabilizer in comparison with other Z inducers used (spermine and NiCl 2 ). This result was confirmed by free energy calculations. Chirality 27:773–778, 2015 . © 2015 Wiley Periodicals, Inc.

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