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Structural Features and Asymmetric Environment of i ‐Pr‐SPRIX Ligand
Author(s) -
Takenaka Kazuhiro,
Lin Xianjin,
Takizawa Shinobu,
Sasai Hiroaki
Publication year - 2015
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22467
Subject(s) - chemistry , ligand (biochemistry) , computational chemistry , stereochemistry , biochemistry , receptor
Abstract Novel chiral diisopropyl spiro bis(isoxazoline) ligands, anti‐i ‐Pr‐SPRIX and syn‐i ‐Pr‐SPRIX, were designed and synthesized. Their catalytic utility, X‐ray crystallographic analyses, and complexation studies demonstrated the structural features of tetraisopropyl spiro bis(isoxazoline) ligand, i ‐Pr‐SPRIX, which is a prominent ligand in various enantioselective Pd catalytic processes: All i ‐Pr groups work in collaboration to create an effective asymmetric environment. Chirality 27:532–537, 2015 . © 2015 Wiley Periodicals, Inc.