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Preferential Enrichment of DL ‐Leucine Using Cocrystal Formation With Oxalic Acid Under Nonequilibrium Crystallization Conditions
Author(s) -
Manoj Kochunnoonny,
Takahashi Hiroki,
Morita Yoko,
Gonnade Rajesh G.,
Iwama Sekai,
Tsue Hirohito,
Tamura Rui
Publication year - 2015
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22431
Subject(s) - chemistry , cocrystal , oxalic acid , crystallization , enantiomer , leucine , crystallography , resolution (logic) , stereochemistry , amino acid , inorganic chemistry , organic chemistry , biochemistry , molecule , hydrogen bond , artificial intelligence , computer science
By utilizing the preferential enrichment (PE) technique, we achieved an improved enantiomeric resolution of DL ‐leucine (Leu) using a 1:1 cocrystal ( DL ‐ 1 ) of DL ‐Leu and oxalic acid. The crystal structure analysis of DL ‐ 1 indicated the occurrence of a novel type of phase transition and subsequent preferential redissolution of one enantiomer from the resulting crystals into solution. Chirality 27:405–410 2015 . © 2015 Wiley Periodicals, Inc.