Preferential Enrichment of  DL ‐Leucine Using Cocrystal Formation With Oxalic Acid Under Nonequilibrium Crystallization Conditions | Zendy

Manoj Kochunnoonny | Zendy; Takahashi Hiroki | Zendy; Morita Yoko | Zendy; Gonnade Rajesh G. | Zendy; Iwama Sekai | Zendy; Tsue Hirohito | Zendy; Tamura Rui | Zendy

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Preferential Enrichment of DL ‐Leucine Using Cocrystal Formation With Oxalic Acid Under Nonequilibrium Crystallization Conditions

Author(s) -

Manoj Kochunnoonny,

Takahashi Hiroki,

Morita Yoko,

Gonnade Rajesh G.,

Iwama Sekai,

Tsue Hirohito,

Tamura Rui

Publication year - 2015

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.22431

Subject(s) - chemistry , cocrystal , oxalic acid , crystallization , enantiomer , leucine , crystallography , resolution (logic) , stereochemistry , amino acid , inorganic chemistry , organic chemistry , biochemistry , molecule , hydrogen bond , artificial intelligence , computer science

By utilizing the preferential enrichment (PE) technique, we achieved an improved enantiomeric resolution of DL ‐leucine (Leu) using a 1:1 cocrystal ( DL ‐ 1 ) of DL ‐Leu and oxalic acid. The crystal structure analysis of DL ‐ 1 indicated the occurrence of a novel type of phase transition and subsequent preferential redissolution of one enantiomer from the resulting crystals into solution. Chirality 27:405–410 2015 . © 2015 Wiley Periodicals, Inc.

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