Premium
Synergistic Effects of Trace Amounts of Water in the Enantiodiscrimination Processes by Lipodex E: A Spectroscopic and Computational Investigation
Author(s) -
UccelloBarretta Gloria,
Schurig Volker,
Balzano Federica,
Vanni Letizia,
Aiello Federica,
Mori Mattia,
Ghirga Francesca
Publication year - 2015
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22394
Subject(s) - chemistry , trace (psycholinguistics) , computational chemistry , organic chemistry , philosophy , linguistics
Nuclear magnetic resonance (NMR) investigations on mixtures containing octakis(3‐ O ‐butanoyl‐2,6‐di‐ O ‐pentyl)‐γ‐cyclodextrin (Lipodex E) and each enantiomer of methyl‐2‐chloropropionate (MCP) ascertained the role of trace amounts of water in the enantiodiscrimination processes. Water is deeply included into the cyclodextrin and favors the formation of the inclusion complex with ( S )‐MCP, whereas ( R )‐MCP is only slightly affected, thus causing a significant increase of NMR differentiation. Molecular dynamics simulations were performed to shed light on the possible behavior of Lipodex E in different conditions (i.e., solvent, inclusion complexes), providing energetic and atomistic details that are in agreement with NMR observations. Chirality 27:95–103, 2014 . © 2014 Wiley Periodicals, Inc.