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Fractional Reactive Extraction for Symmetrical Separation of 4‐Nitro‐D,L‐Phenylalanine in Centrifugal Contactor Separators: Experiments and Modeling
Author(s) -
Tang Kewen,
Wen Ping,
Zhang Panliang,
Huang Yan
Publication year - 2015
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22392
Subject(s) - chemistry , contactor , countercurrent exchange , extraction (chemistry) , enantiomer , chromatography , enantioselective synthesis , cascade , phenylalanine , nitro , yield (engineering) , analytical chemistry (journal) , thermodynamics , organic chemistry , catalysis , power (physics) , physics , biochemistry , alkyl , amino acid
The enantioselective liquid–liquid extraction of 4‐nitro‐D,L‐phenylalanine (D,L‐Nphy) using PdCl 2 {(s)‐BINAP} as extractant in dichloroethane was studied experimentally in a countercurrent cascade of 10 centrifugal contactor separators (CCSs) at 5°C, involving flow ratio, extractant concentration, and Cl − concentration. The steady‐state enantiomeric excess ( ee ) in both stream exits was 90.86% at a 93.29% yield. The predicted value was modeled using an equilibrium stage approach. The correlation between model and experiment was satisfactory. The model was applied to optimize the production of both enantiomers in >97% ee and >99% ee . 14 stages and 16 stages are required for 97% ee and 99% ee for both enantiomers, respectively. Chirality 27:75–81, 2015 . © 2014 Wiley Periodicals, Inc.