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Studies Towards the Synthesis of Medermycin via Dötz Benzannulation
Author(s) -
Qu Chunrong,
Tang Erqing,
Loeppky Richard,
Deng Zixin,
Pulley Shon R.,
Hong Xuechuan
Publication year - 2015
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22383
Subject(s) - chemistry , nitrile , chirality (physics) , carbene , halogenation , carbamate , organic chemistry , combinatorial chemistry , catalysis , medicinal chemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
The C ‐arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O ‐carbamate directed ipso bromination and nitrile substitution in good overall yields. Chirality 27:18–22, 2015 . © 2014 Wiley Periodicals, Inc.