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Synthesis, Enzymatic Resolution , and Stereochemical Characterization of Isoparaconic Acid Derivatives: A Combined Experimental and Theoretical Investigation
Author(s) -
Felluga Fulvia,
Forzato Cristina,
Mazzeo Giuseppe,
Nitti Patrizia,
Pitacco Giuliana,
Superchi Stefano
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22355
Subject(s) - chemistry , resolution (logic) , kinetic resolution , enzyme , characterization (materials science) , computational chemistry , solvent , enzyme catalysis , organic chemistry , stereochemistry , combinatorial chemistry , catalysis , nanotechnology , enantioselective synthesis , materials science , artificial intelligence , computer science
Enantiomerically enriched isoparaconic acid derivatives were obtained by kinetic enzymatic resolution . To explain the solvent dependence observed for their optical rotatory power a computational investigation of their chiroptical properties was performed. Chirality 26:640–650, 2014. © 2014 Wiley Periodicals, Inc.