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Synthesis of Indolyldiketopiperazines with NBS
Author(s) -
Ma Yangmin,
Ren Decheng,
Wu Hao,
Zhang Jin,
Feng Tingting,
Li Yanchao
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22346
Subject(s) - chemistry , succinimide , reagent , elemental analysis , carboxylate , organic chemistry , stereochemistry , combinatorial chemistry
ABSTRACT Two series of indolyldiketopiperazines were synthesized starting from methyl 1‐substituted‐1,2,3,4‐tetrahydro‐ β ‐carboline‐3‐carboxylate hydrochlorides via N ‐bromo‐succinimide (NBS) as an important reagent. All eight compounds were characterized by nuclear magnetic resonance (NMR) and elemental analysis. Furthermore, the mechanisms of NBS‐reacted rearrangements are also discussed. Chirality 26:790–792, 2014 . © 2014 Wiley Periodicals, Inc.