Circular Dichroism Sensing of Chiral Compounds Using an Achiral Metal Complex as Probe | Zendy

Irfanoglu Burcin | Zendy; Wolf Christian | Zendy

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Circular Dichroism Sensing of Chiral Compounds Using an Achiral Metal Complex as Probe

Author(s) -

Irfanoglu Burcin,

Wolf Christian

Publication year - 2014

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.22332

Subject(s) - chirality (physics) , chemistry , circular dichroism , enantiomer , cobalt , enantiomeric excess , substrate (aquarium) , metal , ligand (biochemistry) , combinatorial chemistry , enantioselective synthesis , photochemistry , stereochemistry , crystallography , organic chemistry , catalysis , chiral symmetry breaking , biochemistry , physics , oceanography , receptor , quantum mechanics , geology , nambu–jona lasinio model , quark

Coordination of a chiral substrate to ( meso ‐salen)cobalt(II) nitrate and subsequent oxidation generates a Co(III) complex exhibiting a strong chiroptical readout that is attributed to spontaneous substrate‐to‐ligand chirality imprinting. The characteristic circular dichroism (CD) response of the (salen)cobalt complex can be used for enantiomeric analysis of a variety of chiral substrates based on a simple CD measurement at low concentration and without additional purification steps. This chirality sensing approach has potential for high‐throughput enantiomeric excess ( ee) screening applications and minimizes solvent waste production. Chirality 26:379–384, 2014 . © 2014 Wiley Periodicals, Inc.

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