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On the Complementarity of ECD and VCD Techniques
Author(s) -
Nicu Valentin Paul,
Mándi Attila,
Kurtán Tibor,
Polavarapu Prasad L.
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22330
Subject(s) - chemistry , complementarity (molecular biology) , vibrational circular dichroism , circular dichroism , conformational isomerism , molecule , resolution (logic) , characterization (materials science) , computational chemistry , crystallography , nanotechnology , organic chemistry , artificial intelligence , genetics , materials science , computer science , biology
An unprecedented complementarity of electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopic techniques is demonstrated by showing that each technique reveals the structure of a different molecular segment. Using a flexible molecule of biological significance we show that the synergetic use of ECD and VCD yields more complete structural characterization as it provides improved and more reliable conformer resolution. Chirality 26:525–531, 2014 . © 2014 Wiley Periodicals, Inc.