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Preparation and Enantioselectivity Binding Studies of a New Chiral Cobalt(II)porphyrin‐Tröger's Base Conjugate
Author(s) -
Tatar Ameneh,
Valík Martin,
Novotná Jana,
Havlík Martin,
Dolenský Bohumil,
Král Vladimír,
Urbanová Marie
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22327
Subject(s) - chemistry , conjugate , porphyrin , cobalt , base (topology) , combinatorial chemistry , stereochemistry , organic chemistry , mathematics , mathematical analysis
A new bis[cobalt(II)porphyrin]‐Tröger's base conjugate was studied as a potential receptor for methyl esters of several amino acids . The conjugate was prepared as racemate, and then resolved via preparative high‐performance liquid chromatography (HPLC) on a chiral column. The high affinity to lysine, histidine, and proline methyl esters was found by complexation studies followed by UV‐Vis spectroscopy. The studies of pure enantiomers, followed by UV‐Vis and electronic circular dichroism spectroscopy, revealed the highest enantioselectivity for lysine methyl ester. Chirality 26:361–367, 2014 . © 2014 Wiley Periodicals, Inc.