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Enantioselective Acute Toxicity Effects and Bioaccumulation of Furalaxyl in the Earthworm ( Eisenia foetida )
Author(s) -
Qin Fang,
Gao Yongxin,
Guo Baoyuan,
Xu Peng,
Li Jianzhong,
Wang Huili
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22323
Subject(s) - earthworm , bioaccumulation , chemistry , enantiomer , acute toxicity , toxicity , enantioselective synthesis , environmental chemistry , stereochemistry , biochemistry , ecology , organic chemistry , biology , catalysis
The enantioselectivities of individual enantiomers of furalaxyl in acute toxicity and bioaccumulation in the earthworm ( Eisenia foetida ) were studied. The acute toxicity was tested by filter paper contact test. After 48 h of exposure, the calculated LC 50 values of the R ‐form, rac ‐form, and S ‐form were 2.27, 2.08, and 1.22 µg cm ‐2 , respectively. After 72 h of exposure, the calculated LC 50 values were 1.90, 1.54, and 1.00 µg cm ‐2 , respectively. Therefore, the acute toxicity of furalaxyl enantiomers was enantioselective . During the bioaccumulation experiment, the enantiomer fraction of furalaxyl in earthworm tissue was observed to deviate from 0.50 and maintained a range of 0.55–0.60; in other words, the bioaccumulation of furalaxyl was enantioselective in earthworm tissue with a preferential accumulation of S ‐furalaxyl. The uptake kinetic of furalaxyl enantiomers fitted the first‐order kinetics well and the calculated kinetic parameters were consistent with the low accumulation efficiency. Chirality 26:307–312, 2014 . © 2014 Wiley Periodicals, Inc.