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Reaction Monitoring Using Mid‐Infrared Laser‐Based Vibrational Circular Dichroism
Author(s) -
Rüther Anja,
Pfeifer Marcel,
LórenzFonfría Víctor A.,
Lüdeke Steffen
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22307
Subject(s) - chemistry , vibrational circular dichroism , sparteine , analytical chemistry (journal) , infrared , infrared spectroscopy , laser , circular dichroism , stereochemistry , optics , organic chemistry , physics
Changes in vibrational circular dichroism (VCD) were recorded on‐line during a chemical reaction. The chiral complex nickel‐(–)‐sparteine chloride was hydrolyzed to free (–)‐sparteine base in a biphasic system of sodium hydroxide solution and chloroform (CHCl 3 ). Infrared (IR) and VCD spectra were iteratively recorded after pumping a sample from the CHCl 3 phase through a lab‐built VCD spectrometer equipped with a tunable mid‐IR quantum cascade laser light source, which allows for VCD measurements even in the presence of strongly absorbing backgrounds. Time‐dependent VCD spectra were analyzed by singular value decomposition and global exponential fitting. Spectral features corresponding to the complex and free (–)‐sparteine could be clearly identified in the fitted amplitude spectrum, which was associated with an exponential decay with an apparent time constant of 127 min ( t ½ = 88 min). Chirality 26:490–496, 2014 . © 2014 Wiley Periodicals, Inc.