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Selective Bromocyclization of 2‐Geranylphenols Promoted by Phosphite–Urea Cooperative Catalysts
Author(s) -
Sawamura Yasuhiro,
Nakatsuji Hidefumi,
Akakura Matsujiro,
Sakakura Akira,
Ishihara Kazuaki
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22297
Subject(s) - chemistry , steric effects , urea , nucleophile , catalysis , chirality (physics) , medicinal chemistry , bent molecular geometry , organic chemistry , stereochemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Nucleophilic phosphite–urea cooperative catalysts are highly efficient for the bromonium‐induced cyclization of 2‐geranylphenols. Phosphite– N,N ’‐dimethylurea catalysts also show moderate activity, probably due to the steric effect of their bent conformation. Chirality 26:355–359, 2014. © 2014 Wiley Periodicals, Inc.