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Development and Mechanism of an Enantioselective Bromocycloetherification Reaction via Lewis Base/Chiral Brønsted Acid Cooperative Catalysis
Author(s) -
Denmark Scott E.,
Burk Matthew T.
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22259
Subject(s) - chemistry , enantioselective synthesis , chirality (physics) , brønsted–lowry acid–base theory , lewis acids and bases , catalysis , mechanism (biology) , base (topology) , stereochemistry , organic chemistry , combinatorial chemistry , computational chemistry , chiral symmetry , mathematical analysis , philosophy , physics , mathematics , epistemology , quantum mechanics , nambu–jona lasinio model , quark
The development of a binary catalyst system for bromocycloetherification, consisting of an achiral Lewis base and a chiral Brønsted acid, is described in detail. The results of preliminary kinetic studies are also presented. Chirality 26:343–354, 2013 . © 2013 Wiley Periodicals, Inc.