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β‐Hydroxyamide‐Based Ligands and Their Use in the Enantioselective Borane Reduction of Prochiral Ketones
Author(s) -
Azizoglu Murat,
Erdogan Asli,
Arslan Nevin,
Turgut Yilmaz
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22254
Subject(s) - chemistry , enantioselective synthesis , borane , reduction (mathematics) , ketone , organic chemistry , combinatorial chemistry , catalysis , geometry , mathematics
ABSTRACT Hydroxyamide‐based ligands have occupied a considerable place in asymmetric synthesis. Here we report the synthesis of seven β‐hydroxyamide‐based ligands from the reaction of 2‐hydroxynicotinic acid with chiral amino alcohols and test their effect on the enantioselective reduction of aromatic prochiral ketones with borane in tetrahydofuran (THF). They produce the corresponding secondary alcohols with up to 76% enantiomeric excess ( ee ) and good to excellent yields (86‐99%). Chirality 26:21–26, 2013 . © 2013 Wiley Periodicals, Inc.