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A New Enantioselective Synthesis of the Anticonvulsant Drug Pregabalin (Lyrica) Based on a Hydrolytic Kinetic Resolution Method
Author(s) -
Mujahid Mohammad,
Muthukrishnan Murugan
Publication year - 2013
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22253
Subject(s) - chemistry , enantioselective synthesis , kinetic resolution , anticonvulsant , pregabalin , hydrolysis , combinatorial chemistry , stereochemistry , organic chemistry , epilepsy , catalysis , anesthesia , medicine , neuroscience , biology
A practical and efficient enantioselective synthesis of the anticonvulsant drug pregabalin is described for the first time using Jacobsen's hydrolytic kinetic resolution of a terminal epoxide as a key step and a source of chirality. Chirality 25:965–969, 2013 . © 2013 Wiley Periodicals, Inc.