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Enantioselective Liquid–Liquid Extraction of Zopiclone With Mandelic Acid Ester Derivatives
Author(s) -
Peng Yangfeng,
He Quan,
Zuo Bin,
Niu Haibo,
Tong Tianzhong,
Zhao Hongliang
Publication year - 2013
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22239
Subject(s) - chemistry , enantioselective synthesis , mandelic acid , extraction (chemistry) , chirality (physics) , resolution (logic) , organic chemistry , liquid–liquid extraction , solvent , chromatography , catalysis , chiral symmetry , physics , quantum mechanics , artificial intelligence , computer science , nambu–jona lasinio model , quark
Enantioselective liquid–liquid extraction of zopiclone was conducted by employing a series of (R) ‐mandelic acid esters as chiral extractants. The effects of concentration of extractant, concentration of zopiclone, type of organic solvent, pH value, and temperature on the extraction efficiency were investigated. (R)‐o ‐chloromandelic acid propyl ester was demonstrated to be an efficient chiral extractant for zopiclone resolution with a maximum enantioselectivity of 1.6. Chirality 25:952–956, 2013 . © 2013 Wiley Periodicals, Inc.