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Stereoselective Synthesis of (3 R )‐3‐Alkyl‐4,1‐Benzoxazepine‐2,5‐Diones
Author(s) -
Nisar Bushra,
Raza Abdul Rauf,
Black David Stc.,
Kumar Naresh,
Tahir Muhammad Nawaz
Publication year - 2013
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22227
Subject(s) - chemistry , anthranilic acid , chirality (physics) , alkyl , stereoselectivity , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Novel 3‐alkyl‐4,1‐benzoxazepine‐2,5‐diones were synthesized in good ee exploiting the chiral pool methodology, an economical way of asymmetric synthesis . Various anthranilic acids are coupled with different α‐haloacids to afford N ‐acylated anthranilic acid intermediates which undergo cyclization to (3 R )‐3‐alkyl‐4,1‐benzoxazepines‐2,5‐diones. Chirality 25:865–870, 2013 . © 2013 Wiley Periodicals, Inc.