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Use of Sulfated Cyclofructan 6 and Sulfated Cyclodextrins for the Chiral Separation of Four Basic Pharmaceuticals by Capillary Electrophoresis
Author(s) -
Zhang Yi Jun,
Huang Ming Xian,
Zhang Yu Ping,
Armstrong Daniel Wayne,
Breitbach Zachary S.,
Ryoo Jae Jeong
Publication year - 2013
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22206
Subject(s) - chemistry , capillary electrophoresis , enantiomer , sulfation , chromatography , cyclodextrin , chirality (physics) , electrophoresis , chiral column chromatography , combinatorial chemistry , organic chemistry , biochemistry , chiral symmetry breaking , physics , quark , quantum mechanics , nambu–jona lasinio model
Sulfated cyclofructan 6 (S‐CF6) and sulfated cyclodextrins (S‐α‐, β‐, γ‐CDs) are highly selective chiral selectors for the enantioseparation of basic solutes. In this study, S‐CF6 was introduced for the enantiomeric separation of four basic pharmaceuticals (including tamsulosin, tiropramide, bupivacaine, and norephedrine) by capillary electrophoresis (CE), and the enantiomeric separation performance was compared with S‐α‐, β‐, γ‐CDs. The effects of the chiral selector type, chiral selector concentration, operating voltage, and column temperature were examined and optimized. Excellent resolutions were obtained for all solutes on these chiral selectors. Chirality 25:735–742, 2013 . © 2013 Wiley Periodicals, Inc.