Chiral Discrimination of Ammonium Neurotransmitters by C 3 ‐Symmetric Enantiopure Hemicryptophane Hosts | Zendy

Schmitt Aline | Zendy; Chatelet Bastien | Zendy; Collin Solène | Zendy; Dutasta JeanPierre | Zendy; Martinez Alexandre | Zendy

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Chiral Discrimination of Ammonium Neurotransmitters by C 3 ‐Symmetric Enantiopure Hemicryptophane Hosts

Author(s) -

Schmitt Aline,

Chatelet Bastien,

Collin Solène,

Dutasta JeanPierre,

Martinez Alexandre

Publication year - 2013

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.22195

Subject(s) - enantiopure drug , chemistry , diastereomer , enantiomer , chirality (physics) , molecule , ammonium , stereochemistry , computational chemistry , organic chemistry , enantioselective synthesis , chiral anomaly , catalysis , quantum mechanics , nambu–jona lasinio model , physics , fermion

Enantiopure hemicryptophanes efficiently discriminate chiral ammonium neurotransmitters. The ephedrine and norephedrine molecules associate with hemicryptophane hosts to form 1:1 and 1:2 host‐guest complexes. Binding constants are determined by fitting the 1 H nuclear magnetic resonance (NMR) titration curves to give β 1 and β 2 values, which are used to characterize the diastereomeric and enantiomeric discriminating potentials of the hosts. Chirality 25:47–479, 2013. © 2013 Wiley Periodicals, Inc.

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