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Enantiomeric Separation of 13 New Amphetamine‐Like Designer Drugs by Capillary Electrophoresis , Using Modified‐‐Cyclodextrins
Author(s) -
Burrai Lucia,
Nieddu Maria,
Pirisi Maria Antonietta,
Carta Antonio,
Briguglio Irene,
Boatto Gianpiero
Publication year - 2013
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22185
Subject(s) - chemistry , capillary electrophoresis , enantiomer , acetonitrile , chromatography , electrolyte , chirality (physics) , analyte , methanol , capillary electrochromatography , solvent , electrophoresis , cyclodextrin , organic chemistry , electrode , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
An easy‐to‐prepare chiral CE method for the enantiomeric separation of 13 new amphetamine‐like designer drugs, using CDs as chiral selectors, was developed. Sulfated‐β‐CD was found to be the best chiral selector among the three used (sulfated‐β‐CD, caroboxymethyl‐β‐CD, dimethyl‐β‐CD). The separation of the analytes was achieved in a fused‐silica gel capillary at 20 °C using an applied voltage of +25 kV. The optimized background electrolyte consisted of 63.5 mM H 3 PO 4 and 46.9 mM NaOH in water. Several electrophoretic parameters such as CD type, CD concentration (1 − 40 mg/mL), buffer pH (2.6, 3.6, 5.0, 6.0), length of the capillary (70 − 40 cm total length), amount of the organic solvent (methanol and acetonitrile) were investigated and optimized. Chirality 25:617–621, 2013 . © 2013 Wiley Periodicals, Inc.