Studies of Asymmetric Styrene  Cyclopropanation  with a Rhodium(II) Metallopeptide Catalyst Developed with a High‐Throughput Screen | Zendy

Sambasivan Ramya | Zendy; Ball Zachary T. | Zendy

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Studies of Asymmetric Styrene Cyclopropanation with a Rhodium(II) Metallopeptide Catalyst Developed with a High‐Throughput Screen

Author(s) -

Sambasivan Ramya,

Ball Zachary T.

Publication year - 2013

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.22144

Subject(s) - cyclopropanation , cyclopropane , chemistry , styrene , ligand (biochemistry) , rhodium , catalysis , combinatorial chemistry , enantioselective synthesis , stereochemistry , organic chemistry , copolymer , biochemistry , receptor , ring (chemistry) , polymer

Dirhodium metallopeptides have been developed as selective catalysts for asymmetric cyclopropanation reactions. A selective ligand sequence has been identified by screening on‐bead metallopeptide libraries in a 96‐well plate format. Efficient ligand synthesis and screening allows a 200‐member library to be created and assayed in less than three weeks. These metallopeptides catalyze efficient cyclopropanation of aryldiazoacetates, providing asymmetric access to cyclopropane products in high diastereoselectivity. Chirality 25:493–497, 2013 . © 2013 Wiley Periodicals, Inc.

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