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Circular Dichroism Studies on Intermolecular Interactions of Amphotericin B in Ionic Liquid‐Rich Environments
Author(s) -
Jameson Laramie P.,
Dzyuba Sergei V.
Publication year - 2013
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22142
Subject(s) - chemistry , ionic liquid , circular dichroism , intermolecular force , ionic bonding , solvent , crystallography , ion , molecule , organic chemistry , catalysis
Aggregation of amphotericin B (AmB) in an ionic liquid‐rich environment was investigated using circular dichroism (CD) spectroscopy. It was found that nature of the ionic liquids’ anion had a strong impact not only on the aggregation of AmB, but more importantly on the nature of AmB aggregates, as observed in the asymmetry of the exciton couplet of the aggregate in CD spectra. Unique CD signals for AmB aggregates were observed in three different 1‐butyl‐3‐methylimidazolium ionic liquid solutions: [C 4 ‐mim]Br favored the formation of AmB aggregates that were similar to those found in water, whereas [C 4 ‐mim]BF 4 and [C 4 ‐mim]NO 3 produced AmB aggregates that were different from each other and those found in water. The obtained results suggest that the designer solvent ability of ionic liquids could be expanded to address numerous intermolecular processes. Chirality 25:487‐492, 2013 . © 2013 Wiley Periodicals, Inc.