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O‐Heterocyclic Embeurekols from Embellisia eureka , an Endophyte of Cladanthus arabicus
Author(s) -
Ebrahim Weaam,
Aly Amal H.,
Mándi Attila,
Wray Victor,
Essassi El Mokhtar,
Ouchbani Tarik,
Bouhfid Rachid,
Lin Wenhan,
Proksch Peter,
Kurtán Tibor,
Debbab Abdessamad
Publication year - 2013
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22140
Subject(s) - chemistry , conformational isomerism , chirality (physics) , endophyte , mass spectrometry , stereochemistry , absolute configuration , chiral column chromatography , time dependent density functional theory , organic chemistry , molecule , enantiomer , botany , chromatography , particle physics , physics , chiral symmetry breaking , nambu–jona lasinio model , biology , quark
Three new polyketides (-)-1 , (+)-1 , and 2 ) were isolated from the EtOAc extract of the fungus Embellisia eureka , an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of one‐ and two‐dimensional NMR spectroscopy as well as by high‐resolution mass spectrometry. The absolute configurations of (-)-1 , (+)-1 , and 2 were determined by TDDFT ECD calculations of solution conformers, online HPLC‐ECD analysis, and the modified Mosher method. Chirality 25:250–256, 2013. © 2013 Wiley Periodicals, Inc.