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Enantioanalysis of Pipecolic Acid with Stochastic and Potentiometric Microsensors
Author(s) -
Stefanvan Staden RalucaIoana,
Moldoveanu Iuliana,
Sava DanielFlorin,
KapnissiChristodoulou Constantina,
Staden Jacobus Frederick
Publication year - 2013
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22119
Subject(s) - chemistry , potentiometric titration , pipecolic acid , enantiomer , matrix (chemical analysis) , chirality (physics) , selectivity , enantioselective synthesis , graphite , chromatography , combinatorial chemistry , organic chemistry , amino acid , biochemistry , catalysis , ion , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Stochastic and potentiometric microsensors based on porphyrins and polymeric surfactants such as polysodium N ‐undecanoyl‐ l ‐leucylvanilate and polysodium N ‐undecanoyl‐ l ‐vanilate were developed for enantioselective assay of pipecolic acid. The matrices used for the design of the stochastic sensors were diamond paste and graphite paste, while the matrix used for the design of potentiometric sensors was carbon paste. The response characteristics of the microsensors were determined for the enantiomers of pipecolic acid. The response characteristics, selectivity, and enantioselectivity studies proved that the proposed microsensors can be used for clinical enantioanalysis of pipecolic acid in biological fluids, e.g., urine and whole blood. Chirality 25:114–118, 2013 © 2012 Wiley Periodicals, Inc.