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Noncovalent Immobilization of Ionic‐tagged Box‐Cu(OAc) 2 Complex and Its Application in Asymmetric Henry Reaction
Author(s) -
Li ZhiHuai,
Zhou ZhiMing,
Hao XiaoYan,
Zhang Jun,
Dong Xiao,
Liu YingQiang
Publication year - 2012
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22104
Subject(s) - chemistry , catalysis , ionic liquid , isopropyl , alcohol , chirality (physics) , hydrogen bond , isopropyl alcohol , ionic bonding , non covalent interactions , polymer chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , molecule , ion , chiral symmetry breaking , physics , nambu–jona lasinio model , quark , quantum mechanics
Immobilized Cu(OAc) 2 ‐bis(oxazolines) via hydrogen bonding by SBA‐15 was applied to asymmetric Henry reaction , and good enantioselectivities were obtained (up to 83% ee ) between 2‐methoxybenzaldehyde and CH 3 NO 2 in isopropyl alcohol ( i PrOH). The catalyst could be reused seven times without any obvious loss in enantioselectivity. For the first time, this facile and clean immobilization method is applied to the use of bis(oxazolines) complexes. Chirality 24:1092‐1095, 2012 . © 2012 Wiley Periodicals, Inc.