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Monitoring the On‐line Titration of Enantiomeric Omeprazole Employing Continuous‐flow Capillary Microcoil 1 H NMR Spectroscopy
Author(s) -
Hentschel Petra,
Holtin Karsten,
Steinhauser Lisa,
Albert Klaus
Publication year - 2012
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22099
Subject(s) - chemistry , microcoil , enantiomer , nuclear magnetic resonance spectroscopy , chirality (physics) , proton nmr , titration , spectroscopy , chloroform , analytical chemistry (journal) , stereochemistry , chromatography , organic chemistry , physics , quantum mechanics , electrical engineering , electromagnetic coil , engineering , nambu–jona lasinio model , chiral symmetry breaking , quark
The titration of the ( S )‐enantiomer of omeprazole with the ( R )‐enantiomer in chloroform‐ d 1 is monitored by continuous‐flow capillary microcoil 1 H NMR spectroscopy employing a microcoil with a detection volume of 1.5 µl. The observed changes of the 1 H NMR chemical shifts indicate the formation of a heterochiral ( R , S ) dimer of omeprazole via its sulfinyl group and the NH group of the benzimidazole ring. Chirality 24:1074–1076, 2012. © 2012 Wiley Periodicals, Inc.
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